Thursday, April 12, 2018

08:00-08:50 Coffee, Registration, Poster set-up
08:50-08:55 Opening: Hanjoong Jo
08:55-08:00 Opening Remarks: Robert Nerem, Georgia Institute of Technology
09:00-09:30 Keynote Lecture 1 Chaired by Robert Nerem
W. Robert Taylor , Emory University
The role and impact of wall shear stress on abdominal aortic aneurism formation.
09:30-10:45 Aneurysm Robert Taylor & Luke Timmins
09:30-09:50 David Steinman , University of Toronto
Impact of WSS instabilities on the aneurysm wall: A clinical CFD approach.
09:50-10:10 Anne Robertson, University of Pittsburg
Coupling between the cerebral aneurysm micro-structure and its stiffness and failure properties.
10:10-10:30 Craig Goergen, Purdue University
Hemodynamic Simulations of Murine Dissecting Aneurysm Progression.
10:30-10:45 Fatiesa Sulejmani, Georgia Institute of Technology
Biomechanical analysis of ascending aortic aneurysm using an integrated experimental and computational modeling approach.
10:45-11:10 Coffee break
11:10-12:30 Mechano Signaling 1 Kim van der Heiden & Amir Rezvan
11:10-11:30 Luke Brewster, Emory University
Clinically Relevant Mechanisms of Flow-Mediated Arterial Stiffening in Peripheral Arterial Disease.
11:30-11:50 Paul Evans, University of Sheffield
Shear stress regulates developmental genes in adult endothelial cells: role in atherosclerosis.
11:50-12:10 Yun Fang, University of Chicago
Genetic variance, Cellular Metabolism, and Nanomedicine in Vascular Diseases.
12:10-12:30 Jun-Ichi Abe, University of Texas, MD Anderson Cancer Center
Shear Stress and Senescence.
12:30-14:30 Lunch and Poster Session 1
14:30-15:45 Atherosclerosis 1 Jolanda Wentzel & Luke Brewster
14:30-14:50 Habib Samady, Emory University
Wall Shear Stress, Plaque Vulnerability and Acute Coronary Syndromes.
14:50-15:10 Peter Stone, Harvard University
Role of Local Low Endothelial Shear Stress in Coronary Microvascular and Epicardial Endothelial Dysfunction in Patients with Non-obstructive Coronary Atherosclerosis.
15:10-15:30 Ayla Hoogendoorn, Erasmus Medical Center
The Influence of shear stress metrics on plaque progression in an adult hypercholestrolemic pig model: multimodality Imaging, biomechanics and histology.
15:30-15:45 Charis Costopoulos, University of Cambridge
Incorporation of Plaque Structural Stress in Plaque Assessment and Predication of Future Adverse Clinical Events: Insights from the PROSPECT Study.
15:45-16:10 Coffee break
16:10-17:30 Mechanotransduction Paul Evans & Eno Ebong
16:10-16:30 Stephen White, Manchester Metropolitan University
OSGIN1 and OSGIN2 regulate senescence, autophagy and adhesion of HCAEC and potentially contribute in the process of plaque erosion.
16:30-16:50 Peter Davies, University of Pennsylvania
Association of Endocardial Endothelial Phenotypes with Ventricular Regional Hemodynamics.
16:50-17:10 John Tarbell, The City College of New York
The Endothelial Glycocalyx Component Glypican-1 is Upstream of PECAM-1 in Shear Stress Induced Nitric Oxide Production.
17:10-17:35 Luisa Iruella-Arispe, University of California, Los Angeles
Notch1 and mechanosensing in arteries.
18:00-21:00 Conference Dinner and Drinks - HSRB Cafetaria

Friday, April 13, 2018

08:00-08:50 Coffee, Breakfast and Poster Session
08:50-08:55 Opening: John Oshinski
08:55-09:00 Opening Remarks: Larry McIntire, Georgia Tec and Emory
09:00-09:30 Keynote Lecture 2 Chaired by Larry McIntire
W. Roger Kamm, Massachusetts Institute of Technology
In Vitro Vascular Models of Metastatic Cancer and the blood-Brain Barrier.
09:30-10:45 Mechano Signaling 2 Tzung Hsiai & Stephen White
09:30-109:50 John Shyy, University of California, San Diego
KLF4 Regulation of Ch25h and LXR Mitigates Atherosclerosis Susceptibility.
09:50-10:10 Hanjoong Jo , Emory University
The Role of KLK10, a novel flow-sensitive gene, and its role in endothelial inflammation and atherosclerosis.
10:10-10:30 Robert Krams, Queens Mary University
Genome wide screening of endothelial cells of intact vessels reveals exposed to low shear stress identified a large interacting gene networks between mechanosensitive genes and miRNA.
10:30-10:45 Mabruka Alfaidi, Louisiana State University
The Differential Roles of the Adaptor Proteins, Nck1 and Nck2 in Shear Stress-Induced Endothelial Activation in vitro and in vivo.
10:45-11:10 Coffee break
11:10-11:40 Keynote Lecture 3 Chaired by Ton van der Steen
Elisa Konofagou, Columbia University
Noninvasive Mapping of the vascular Compliance for Disease Staging and Treatment Assessment in Vivo.
11:40-12:35 Imaging John Oshinski & Peter Davies
11:40-12:00 Stas Emelianov, Georgia Institute of Technology
12:00-12:20 Tzung Hsiai, University of California, Los Angeles
Light-Sheet Imaging to Elucidate Cardiovascular Injury and Repair.
12:20-12:35 Khalid Salaita, Emory University
Platelets harness lateral piconewton forces to mediate aggregation.
12:35-14:20 Lunch and Poster Session 2
14:20-15:35 Atherosclerosis 2Frank Gijsen & Sandeep Kumar
14:20-14:40 Peter Weinberg, Imperial College
Determinants of pro-atherogenic shear stress patterns in the thoracic aorta.
14:40-15:00 Abdul Barakat, Ecole Polytechnique
Substrate Regulation of Vascular Endothelial Cell Shape and Aligment.
15:00-15:20 Stephanie Lehoux, McGill University
Increased flow alters mesenchymal stem cell in the atherosclerotic plaque.
15:20-15:35 Matthew Bersi, Yale University
Identification of Regional Mechanical Properties in Murine Thoracic Aortic Aneurysms.
15:35-16:00 Awards, closing and drinks